A case of unexplained breast enlargement in a patient after vaccination with Pfizer/BioNTech against COVID-19, pubmed reports.
True parenchymal changes in the breasts after vaccination against COVID-19 are extremely rare. Equally rare are cases of pseudoangiomatous stromal hyperplasia (PASH)-associated gigantomastia.
The patient in this case reported massive breast enlargement one week after receiving the Pfizer/BioNTech COVID-19 vaccine, which worsened after her second dose.
The definitive treatment was achieved by reduction mammoplasty, with the final pathology report confirming uniformly dense terminal duct lobular units with scattered PASH units.
The association between the COVID-19 vaccine, PASH, and breast hypertrophy requires further investigation to understand the spectrum of vaccine reactions, the specialized website states.