Israeli police arrested at least six people in Tel Aviv after clashes broke out between police and protesters, AFP reported.
The protesters demanded a deal with "Hamas" on the release of hostages and early elections.
Protesters marched to the building of Israel's largest Histadrut trade union to call on its president Arnon Ben-David to call a general strike to protest the government of Prime Minister Benjamin Netanyahu and the return of the hostages. held by Hamas in Gaza.
In response, police forces used a specialized acoustic device known as a "sound cannon" to disperse the protesters.
In addition, Israeli media reported that police handed out leaflets to anti-government protesters warning of two-year prison sentences for demonstrators.